一、基本信息

孙世国，教授，博士研究生导师。绿洲学者，石河子大学特聘教授。Scientific Reports等期刊编委，Journal of the American Chemical Society(JACS)等20种国际学术期刊，以及部分国内学术期刊审稿人。发表论文160余篇，其中SCI收录150余篇，入选综合化学类期刊2019 Top 1% 高被引中国作者。先后主持NSFC-新疆联合基金重点项目1项，国家自然科学基金面上项目5项，省部级课题10余项。获授权中国发明专利37项（排名第一7项）、美国专利4项。参编英文书籍2部，获省部级科技奖励4项（一等奖1项，三等奖3项）。主要研究方向：功能材料及其光、电化学、影像学，包括荧光可视化检测材料在医药卫生、环境监测、食品安全等相关领域的应用；系统靶向药剂学（Systematic Targeting Pharmaceutics, STP）包括组合药物、药物在体可视化成像追踪、药物靶向传递、精准定位、智能释放、安全给药等；光/电便携式可视化检测器件及材料开发。

二、主持科学研究项目

1.  NSFC-新疆联合基金重点项目，U1803283，《宫颈癌多靶点精准控释给药及其作用机制研究》。

2.  国家自然科学基金面上项目，21878249，《HIV专一快速荧光可视化检测研究》。

3.  兵团重点领域科技攻关项目，2018AB012，《新疆甘草种植与药材质量提升关键技术研究》。

4.  自然科学基金面上项目，21472016，《肿瘤淋巴转移监测用三重靶向近红外荧光造影研究》。

5.  自然科学基金面上项目，21272030，《分子内与分子间协同作用型红绿光双发射ECL染料标记物研究》。

三、讲授课程

硕士研究生：高级药理学、药学研究方法与论文写作

四、代表性成果

1.  代表论文

[1] Zhenfu Wen, Fengyu Liu*, Guoxin Liu, Qinyan Sun, Yuhuan Zhang, Mehdi Muhammad, Yongqian Xu, Hongjuan Li, Shiguo Sun*, Assembly of multifunction dyes and heat shock protein 90 inhibitor coupled to bovine serum albumin in nanoparticles for multimodal photodynamic/photothermal/chemo-therapy, J. Colloid Interf. Sci., 2021, 590, 290-300.

[2] Zhenzhen Xie, Jia Wen, Shaowei Sun, Jing Zhang, Xiling Deng, Shichao Han, Lixia Wang, Bo Zhang, Chenglin Hong*, Shiguo Sun*, In-vitro and in-vivo monitoring of gold(III) ions from intermediate metabolite of sodium aurothiomalate through water-soluble ruthenium (II) complex-based luminescent probe, Bioorg. Chem., 2021, 110, 104749.

[3] Yasamin Nasiri Khonsari; Shiguo Sun*, A novel MIP-ECL sensor based on RGO-CeO₂NP/Ru(bpy)₃²⁺-chitosan for ultratrace determination of trimipramine, J. Mater. Chem. B, 2021, 9(2), 471-478.

[4] Junna Lu, Fengyu Liu, Hongjuan Li, Yongqian Xu, Shiguo Sun*, Width-Consistent Mesoporous Silica Nanorods with a Precisely Controlled Aspect Ratio for Lysosome Dysfunctional Synergistic Chemotherapy/Photothermal Therapy/Starvation Therapy/Oxidative Therapy. ACS Appl. Mater. Inter., 2020, 12(22), 24611-24622.

[5] Jing Zhang, Zihao Yang, Shanshan Zhang, Zhenzhen Xie, Shichao Han, Lixia Wang, Bo Zhang*, Shiguo Sun*, Investigation of endogenous malondialdehyde through fluorescent probe MDA-6 during oxidative stress, Anal. Chim. Acta, 2020, 1116, 9-15.

[6] Zijian Zhang, Ting Lv, Binbin Tao, Zhenfu Wen, Yongqian Xu, Hongjuan Li, Fengyu Liu*, Shiguo Sun*, A novel fluorescent probe based on naphthalimide for imaging nitroreductase (NTR) in bacteria and cells. Bioorg. Med. Chem., 2020, 28(3), 115280.

[7] Jia Wen^#, Yinghua Lv^#, Yongqian Xu, Pengfei Zhang, Hongjuan Li, Xiaoxu Chen, Xueliang Li, Lingkai Zhang, Fengyu Liu*, Wenxian Zeng*, Shiguo Sun*, Construction of a biodegradable, versatile nanocarrier for optional combination cancer therapy, Acta Biomater., 2019, 83, 359-371.

[8] Tianjiao Li^#, Qiwen Chen^#, Yi Zheng, Pengfei Zhang, Xiaoxu Chen, Junna Lu, Yinghua Lv, Shiguo Sun*, Wenxian Zeng*, PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells, Stem Cell Res. Ther., 2019, 10, 399.

[9] Yasamin Nasiri Khonsari, Shiguo Sun*, A novel label free electrochemiluminescent aptasensor for the detection of lysozyme, Mater. Sci. Eng. C, 2019, 96, 146-152.

[10] Zhenfu Wen, Fengyu Liu*, Qing Chen, Yongqian Xu, Hongjuan Li, Shiguo Sun*, Recent development on biodegradable nanovehicle delivery system-assisted immunotherapy, Biomater. Sci., 2019, 7, 4414-4443.

[11] Junna Lu, Qiwen Chen, Xingcheng Ding, Jia Wen, Yuhuan Zhang, Hongjuan Li, Yongqian Xu, Fengyu Liu*, Su-Shing Chen*, Shiguo Sun*, BSA modified, disulfide-bridged mesoporous silica with low biotoxicity for dual-responsive drug delivery, Micropor. Mesopor. Mat., 2019, 278, 256-266.

[12] Jia Wen, Kui Yang, Xingcheng Ding, Hongjuan Li, Yongqian Xu, Fengyu Liu*, Shiguo Sun*, In situ formation of homogeneous tellurium nanodots in paclitaxel-loaded MgAl layered double hydroxide gated mesoporous silica nanoparticles for synergistic chemo/PDT/PTT trimode combinatorial therapy, Inorg. Chem., 2019, 58, 2987-2996.

[13] Wan Zhang, Xiaoqian Ji, Kunlin Chen, Chaoxia Wang*, Shiguo Sun*, Thermochromic performance of a new temperature sensitive pigment based on rhodamine derivative in both liquid and solid systems, Prog. Org. Coat., 2019, 137, 105280.

[14] Fengyu Liu*, Jia Wen, Su-Shing Chen*, Shiguo Sun*, A luminescent bimetallic iridium(III) complex for ratiometric tracking intracellular viscosity, Chem. Commun., 2018, 54, 1371-1374.

[15] Ting Lv, Yongqian Xu, Hongjuan Li, Fengyu Liu*, Shiguo Sun*, A Rhodamine B-based fluorescent probe for imaging Cu²⁺ in maize roots, Bioorgan. Med. Chem., 2018, 26, 1448-1452.

[16] Jia Wen^#, Yinghua Lv^#, Pengyi Xia^#, Fengyu Liu*, Yongqian Xu, Hongjuan Li, Su-Shing Chen*, Shiguo Sun*, A water-soluble near-infrared fluorescent probe for specific Pd²⁺ detection, Bioorgan. Med. Chem., 2018, 26, 931-937.

[17] Yasamin Nasiri Khonsari, Shiguo Sun*, Electrochemiluminescent aptasensor for thrombin using nitrogen-doped graphene quantum dots, Microchim. Acta, 2018, 185, 430.

2.  发明专利

[1] 孙世国，慕道洲，彭孝军，蔡明珠，王继涛，光敏染料锇配合物及其制备方法、癌变早期DNA氧化损伤快速检测试剂盒及其检测方法，中国发明专利，ZL201310148539.7。

[2] 孙世国，王继涛，彭孝军，慕道洲，孙伟，一类双波长发射、双异核金属配合物、其制备方法及应用，中国发明专利，ZL201310224080.4。

[3] 孙世国，彭孝军，李志勇，王继涛，八元瓜环自组装型分子信标及其制备方法和应用，中国发明专利，ZL201310379653.0。

[4] 孙世国，孙立成，杨洋，彭孝军，樊江莉，刘凤玉。分子内带有吩噻嗪供电基团的三联吡啶钌/锇ECL标记物，中国发明专利，ZL200910011139.5。

[5] 孙世国，孙立成，杨洋，彭孝军，樊江莉，刘凤玉。以不同长度碳链连接的双核三联吡啶钌/锇ECL标示物，中国发明专利，ZL200910011299.X。

[6] 孙世国，刘凤玉，李福胜，染料与八元瓜环自组装化合物用于作为荧光探针的应用，中国发明专利，ZL201110154078.5。

五、联系方式

1.  E-mail：sunsg@nwsuaf.edu.cn

2.  通讯地址：新疆维吾尔自治区石河子市，北2路59号，石河子大学医学校区，太阳成集团tyc33455cc

3.  邮编：832002